Among the greatest risks to the planet are the challenges in tackling climate and environmental changes, as well as in anticipating and preventing the scale and complexity of water-related crises. The imminent collapse of water resources in many countries, along with a lack of understanding of the mechanisms behind the dysfunction of various components of the water cycle, disproportionately impacts the most vulnerable communities and nations, thereby worsening inequalities. The UNESCO Chair in Global Environmental Changes aims to support the latest advances in scientific research, new data, and technological solutions within a framework that promotes international exchanges and collaborations. Supported by more than 50 collaborators worldwide, the chair envisions integrated and systemic solutions acceptable to communities to secure water resources, reduce the impacts of environmental changes, and bridge gaps in equity, science, technology, and innovation within and between countries.